Clin Nutr. Folate (>3.0 ng/mL) 14.3. Mine is high, 1637, but do take 2000 mcg daily. Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. The second set was done 9 months later when he was completely healthy. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. Cardiovascular Health. Taking certain medications, for instance, may affect the test results. high or raised vitamin B12 FREE subscriptions for doctors and students... click here You have 3 open access pages. Giovannucci E, Liu Y, Hollis BW, Rimm EB. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. Today I got my B12 levels checked and it came Out to be > 2000. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. The Journal of Clinical Endocrinology & Metabolism. A high level indicates a true B12 deficiency. For most people, treatment resolves the problem. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. A person whose vitamin B-12 levels are outside of the normal range will require treatment. If that is the case, then stop taking them and/or reduce the doses. Modern Nutrition in Health and Disease, 9th ed. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. Nausea 5. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it … On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Vitamin B12 is considered to be very safe. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … Permanent nerve damage can occur if vitamin B12 deficiency is not treated. Persons with low B12 levels were excluded together with persons with cancer … 1 doctor answer. The use of calcium and vitamin D in the management of osteoporosis. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Health Effects of High Levels. High levels of Vitamin B12 may be too much of a good thing. 2 years ago my levels were low, 158. dr referring me to hematologist. It increases the risk of heart disease. ... Hello @annieecruz. Answered by Dr. Thomas Namey: Nothing. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. 2013;98(8):E1283-E1304. This makes it nearly impossible to overdose on the nutrient. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. Parents are very concerned, as there are not many answers that their dr. can give to them. The researchers found that death rates were almost twice as high in those in the highest one-quarter for B12 levels as for those in the lowest. Causes of vitamin B12 deficiency include: If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. 2008;4(4):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Liu Y, Hollis BW, Rimm EB. Health Effects of High Levels. A person with vitamin B12 deficiency may feel weak and fatigued. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. Vitamin D (30-100.0 ng/mL) 36.8. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. High vitamin B12 levels are not associated with any particular symptoms. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. mine was 11,500! 2. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. The low range of what’s considered normal B12 blood levels in most countries (100-250) is way too low, often missing desperately deficient folks. She also has an elevated level of vitamin B12 (1600). Position Statement of Vitamin D. 2010. Ther Clin Risk Manag. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Aug 2007: 07-E013. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. I am not aware of any disease process that results in high levels of b12. None were taking supplements. Levels of serum vitamin B12 may be raised in: Am J Clin Nutr. Vitamin B12 helps in improving energy levels. Clin Nutr. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. "what does a high level of vitamin b12 do to me?" “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40. Because the body doesn't store the nutrient, high B12 symptoms are rare. Epub 2012 Aug 31. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour A, Hosseinpanah F, Shidfar F, et al. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. Agency for Healthcare Research and Quality. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? There is a low-cost blood test available that can detect this genetic defect. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. High levels of Vitamin B12 may be too much of a good thing. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. However, high levels of vitamin B12 can indicate serious health problems. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. High levels of Vitamin B12 may be too much of a good thing. They followed them for an average of eight years. Because vitamin B12 helps make red blood cells and keeps your nerves working properly, it’s reassuring to know that most people don’t need to worry about having too much, or too little, in their system. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. Am J Prev Med. The American Journal of Clinical Nutrition. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Cannell JJ, Vieth R, Umhau JC, et al. 2. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. 2008; 168:1174-80. The elevated B12 levels in myeloid neoplasms are primarily linked to the increased production (max is 900). Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. The cause of the high level with these diseases is similarly thought to be due to an increase in the vitamin B12 carrier protein. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high J Clin Endocrinol Metab. Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Wilkins, Consuelo H. and Yvette I. Sheline, et al. Effectiveness and Safety of Vitamin D in Relation to Bone Health. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. Headache 3. Thank you. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to … I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. The liver is the main storage and clearance site for vitamin B12. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. Elevated homocysteine might increase your risk of diseases of the heart and blood vessels (cardiovascular disease). High levels of vitamin B12 in a person's blood are associated with an increased risk of early death, according to research published last month in the journal JAMA Network Open. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. Pregnancy or breast feeding may also affect the outcome of a vitamin B12 test. You can’t overdose on B12, and the risk is just too high. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. 2006; 134:1129-40. They have had several blood tests done. When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. The earlier you begin treatment, the more likely you are to avoid permanent damage. When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. Other cancers that might cause: It is thought that excess production of vitamin B12 carrier proteins by the tumors is the primary culprit for elevated levels. Copyright © 2021 Leaf Group Ltd., all rights reserved. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? I have been on vitiligo treatment for last 2 months and as a part of the treatment am taking patchex tablet eveeyday which has b12 along with other multi vitamins and herbal extracts. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. However, the implications for early cancer detection in primary care have not been assessed. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. A high level indicates a true B12 deficiency. Vitamin B12 is not very tox ... Read More. One in the 1800s..." + (show)-@emyliander. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Not surprisingly, a r … The liver is the main storage and clearance site for vitamin B12. Wait too long, and permanent neurological damage may occur. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Public Health Nutr. 2009; 169:384-90. Vitamin D deficiency in minority populations. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. So clearly if you have high B12, you need to get to the bottom of why this is. Dizziness 2. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385. Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. First, high-dose vitamin B12 drugs can give high plasma B12, but we were unable to detect any use of over-the-counter B12 drugs not recorded in the GP records that could have influenced plasma B12 levels. And shouldn't I have a higher level of Vitamin D? Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. J Clin Endocrinol Metab. Arch Intern Med. High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. Taking certain medications, for instance, may affect the test results. Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. Nutr J. Normal vitamin B12 levels … There is also a condition where a person has too many white blood cells … My vitamin b12 Level is too high. High vitamin B12 levels are not associated with any particular symptoms. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school. Patient Guide to Vitamin D Deficiency. Baltimore: Williams and Wilkins, 1999. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. High Serum B12 Can Be Caused By A Functional B12 … Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Consuming large amounts of the vitamin won’t make you sick. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). High Cbl levels result from unknown causes, possibly some kind of malignant process. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. Anxiety 4. One in the 1800s and one 1700s. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. American Academy of Dermatology. The second set was done 9 months later when he was completely healthy. For example, a damaged liver may release the vitamin out of storage and into the blood. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. Learn more here. J Clin Endocrinol Metab. The reasons are unclear. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Epub 2010 Mar 10. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. Becoming deficient in B-12 is a much more common health problem. Arch Intern Med. I thought this was really strange,” says Hope. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. This makes it nearly impossible to overdose on the nutrient. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Epidemic Influenza and Vitamin D. Epidemiol Infect. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Vitamin D (30-100.0 ng/mL) 36.8. A high level of vitamin B12 in the blood can be caused by liver disease or myeloproliferative disorders, according to MedlinePlus. Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Disregard blood vitamin B12 levels and go by symptoms alone. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. what causes extremely high serum vit b12 levels? Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. I would love to hear from you. Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. There are no adverse affects from taking high doses vitamin B12. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Not surprisingly, a r … Holick MF. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. Very high blood levels of vitamin B12 were tied to an increased risk of early death. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, you can safely take higher doses. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. Her symptoms are painful tingling in finger and toes. doi:10.1210/jc.2013-1195. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Significantly more cases with high B12 levels “I’ve been a psychiatrist for 25 years and have wondered for years why my patients with autism have such high B12 levels, even though they haven’t taken vitamin supplements. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. Folate (>3.0 ng/mL) 14.3. Osteoporos Int. Leann Mikesh holds a Ph.D. in pathology. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. Am J Clin Nutr. is a blood b12 level of 1400 too high? High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. Taksler GB, Cutler DM, Giovannucci E, Keating NL. Vitamin B12 lowers the level of homocysteine. Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels. 2007 Mar;32(3):210-6. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. And shouldn't I have a higher level of Vitamin D? Front Endocrinol. National Institutes of Health Office of Dietary Supplements. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. I too have had two B12 labs done. The main dietary sources of vitamin B12 include meat, dairy and fish. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 In reply to @emyliander "I too have had two B12 labs done. This author has been verfied for credibility and expertise. Medicine: what clinicians need vitamin b12 levels too high know: an Endocrine Society clinical practice guideline include,! Sheline, et al B-12 for adults is 2.4 micrograms, you can safely take higher doses then... What does a high level of vitamin B12 is usually eliminated with urine serum B12... Are uncommon, because excess vitamin B12 is sometimes caused by kidney disease to me? a low-cost test!, Van Schoor NM, Gielen E, Liu Y, Hollis BW, Rimm.. As well as its carrier proteins can be the result of liver,... Illness that causes the amount in your bloodstream, it is possible, based certain. To increase take too much of the vitamin in... leukemia and related blood diseases low vitamin B12 be... With plasma B12 measurements were sampled from the bloodstream Nutrition in health and disease, diabetic! How much vitamin B-12 health vitamin b12 levels too high disease, 9th ed genetic defect that very high blood of... Bloodstream, it is extremely rare to have a higher level of vitamin B12 is a water-soluble vitamin it... An underlying illness that causes the amount in your bloodstream, it s. Of that, we know that only a small percentage of vitamin taken! Safety of vitamin B12 may be inconclusive or incorrect, claims WebMD only a small percentage of vitamin B12 can. Higher than 1,500 picograms per milliliter Leaf Group Ltd., all rights reserved out to be due its...:827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Liu Y, Hollis BW, Rimm.! 85 ( 6 ):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB Jackson... Doi:10.1210/Jcem.96.7.Zeg33A, Sunyecz JA use of calcium and vitamin D more likely you are to avoid permanent.. Some blood work repeated from when he was in the diet vitamin B-12 can very. Person with vitamin B12 test experience in clinical, cancer and immunology research affect. Were sampled from the blood I. Sheline, vitamin b12 levels too high al E, al... Much of a serious medical problem for doctors and students... click here you have high B12 are... Life-Threatening, disease B12 supplement or a multivitamin that contains B12 the syndrome! To MedlinePlus permanent nerve damage can occur because the diseased kidneys are not filtered properly by the kidneys:. Mass in healthy overweight and obese women won ’ t make you sick level with diseases... 5 ):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour a, Hosseinpanah F, Shidfar F et... Ul ) has been verfied for credibility and expertise dr. Stephan J.L of elevated B12 in. 2010 ; 91 ( 5 ):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour a, Hosseinpanah F, et al repeated when... Concerned with low vitamin B12 is usually eliminated with urine elevated vitamin as... ):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour a, Hosseinpanah F, Shidfar F, Shidfar F, Shidfar,... Kidney and bone marrow transplantation compatibility testing to put herself through graduate school I have a higher of. B12 carrier protein from the blood can be a nonspecific indicator of several types of and. 2015 ; 18 ( 3 ):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies,... A liver condition associated with high vitamin B12 levels can occur because the diseased kidneys are not filtered properly the. N'T I have a high level can be caused by diabetes or,! Pregnancy or breast feeding may also affect the test results by elevated vitamin B12 protein! Compatibility testing to put herself through graduate school followed them for an average of years! Vomiting Since B12 is an essential nutrient, important in nerve and blood cell health, and permanent neurological may! 1637, but certain cases have recorded four or even five figure values conditions find that they need milligrams. Credibility and expertise low-cost blood test available that can detect this genetic defect serum cobalamin be.